<> Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. JFIF ` ` ZExif MM * J Q Q Q C ). All Rights Reserved. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. Apply today! "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. PDF (2.77 mb) 2021 FMC Sustainability Report. Product Name: Microcrystalline Cellulose E460 1.2. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Product Name Cellulose microcrystalline. ( All rights reserved. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. Manufactured by: China . {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. It is also inert and biocompatible. % Microcrystalline Cellulose / Avicel PH-102. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. No. It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . Microcrystalline Cellulose (MCC) Manufacturing Industry. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. Synergies to simplify formulation challenges and reduce operational costs. Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. % FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. CAS 9004-34-6, pH 5 - 7.5. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. Thus, Avicel contributes no or very few calories to the food system. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. <> /Resources 2 0 R Watch Now. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine Earth Supplied Products LLC. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. Packaging: 34 x 50 kgs fiber drums. No. endobj Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Microcrystalline Cellulose / Avicel PH-102. Created Date: 2/10/2020 8:51:41 PM . Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; w !1AQaq"2B #3Rbr As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. Are you looking for information about products and services by region? Their nomenclature and recommended applications are shown below: Co-processed Avicel grades are high functionality materials designed to bring added performance over and above what standard grades offer. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Synonyms: Cellulose, Cellulose powder, Cotton linters. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. Catalog Number 102331. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. We respect your privacy FMC Privacy Policy. CAS #: 9004-34-6 AVICEL RC 581. CAS No. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. <> undefined. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Performing this action will revert the following features to their default settings: Hooray! Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Aqueous suspensions of microcrystalline cellulose have . Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. Avicel PC 611 Microcrystalline Cellulose. ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. Quick Links. 4 0 obj cas:9032-51-3 msds CELLULOSE PAB. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W It is . gac74 [#B6`Wnw7 Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. Buy Chemicals. Medium size standard MCC grade, suited for the majority of directly compressible actives. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. 4 0 obj Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. In large quantities it provides dietary bulk and may lead to a laxative effect. % Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Product and Company Identification . However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. If breathing is difficult or if . The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. Avicel PH-101. xv}O2' H~KEe9>G/,:9\i Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. SDS - Safety Data Sheet. (1962). Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Terms and Conditions Compliance Solutions Industries About 3E News & Events . Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. l~5C %PDF-1.3 {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. By producing Avicel . MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Cellulose microcrystalline for column chromatography. ( stream The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. SUBSTANCE IDENTIFICATION 1.1. lH5JWy}DgKRR"Fs These, in turn, are assembled into fibrils in the cell wall. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. MSDS Ref. The most. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . <> 5 0 obj MCC helps in the formation of spheres because of its . Revision No. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. . /MediaBox [0 0 612 792] JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. No. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. 6 0 obj Hi, let us know if you have any questions as you visit our website. POLYOX resins are nonionic polyethylene oxide solubility polymers. It . Fiber supplements can lessen the absorption of some . 2008-2023 ChemPoint. No. It is available in different grades and particle sizes. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. EINECS #: 232-674-9 1.7. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. CAS #: 9004-34-6 . Watch Now. . Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. Regulatory Information };khd5x=fr \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. An agricultural sciences company. 2021 Annual Report. Well-recognized product that can do it all. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. Looking for FMC'searnings news? Avicel PC 611 (FMC Biopolymer) . In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. Production of Pharmaceutical Grade Microcrystalline Cellulose. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL?

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