Its mainly a solvent for ingredients that do not like to dissolve in oils but rather in water. What order you use them in will depend on what products you are using. It also mildlyexfoliatesthe skin, curtails redness and reduces the appearance of hyperpigmentation. . Vitamin C or Ascorbic acid brightens the skin tone and also reduces the signs of aging. Ouch!, Thats a hell of a high concentration right? Usually, it comes to the formulaas part of a preservativeblendas it's not enough on its own. Think of retinol as tretinoins gentler cousin. Sorry if this has been asked but when can I start to incorporate azelaic acid? You should not mix tretinoin with other topical acne treatments, such as benzoyl peroxide or salicylic acid. A helper ingredient that's used as a co-emulsifier (meaning next to other emulsifiers in the formula it helps water and oil to mix) and as a stabilization agent for foams. Azelaic Acid. Skincare is more popular than ever, but with great ingredients comes a great responsibility to know what those ingredients do. Tretinoin and niacinamide are two powerful skincare ingredients that can be used together for some amazing skin benefits. Its approved by Ecocert and also used in the food industry(E415). When it infects humans, it lightens patches of skin. By this I mean, use azelaic acid in the morning, while you use retinol at night but still maintain the every-other-day application method. The preparation is applied to the affected area once to twice daily and the ingredients work synergistically together to decrease redness and pimples. An error has occurred. Topical tretinoin is effective in reducing fine lines, hyperpigmentation, roughness, and laxity associated with photodamaged skin. Bottom line. A real oldie but a goodie. Normal (well kind of - it's purified and deionized) water. A randomised investigator-blind parallel-group study to assess efficacy and safety of azelaic acid 15% gel vs. adapalene 0.1% gel in the treatment and maintenance treatment of female adult acne. Niacinamide is known to promote collagen production that makes the skin Tretinoin - superstar. A prescription from a medical provider (like your Curology provider!). Khi kt hp Tretinoin vi Azelaic . Learn how popular skincare ingredients like Azelaic acid, Niacinamide, Retinol, Salicylic acid, and Tretinoin can help treat acne, anti-aging, and hyperpigmentation, and more common skin concerns. What it is: A skin-lightener produced by a fungus, Pityrosporum Ovale. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome . That's why our products contain acne-fighting ingredients like azelaic acid, tretinoin, niacinamide, and clindamycin to help you achieve your best skin. With salicylic acid, niacinamide effectively banishes breakouts by regulating oil production, reducing clogged pores, and exfoliating the skin, she says. . Be the first to rate this post. Elizabeth is the owner of The Blushing Bliss, a skincare and beauty blog that she started to order to help others navigate the overwhelming world of skincare. Then you'll love to like our Facebook I had some on my right cheek, some on my left cheek and one on my forehead. Well, Ive been a long-time acid-user, (even though I have a sensitive skin), I technically know my way around acids and how to properly use them to avoid inflammatory-irritation. Also-called: All-Trans-Retinoic Acid, Form of Retinoids | What-it-does: cell-communicating ingredient. It is also difficult to find a single product that is effective in treating both acne vulgaris and rosacea. conjugated retinoid cream vs 1.0% retinol cream or 0.025% tretinoin cream in . Word of advice, stick to using this potent cocktail in your evening skincare routine as both ingredients increase the photosensitivity of the skin. I have tonnes of purging and some very intense PIE. In this post well be discussing everything you need to know about these two powerhouse ingredients, including what they do, the benefits of using them and how to properly mix them together. (We also checkedProspector for sodium hyaluronate versions actually used in cosmetic products and found that the most common molecular weight was 1.5-1.8 million Da that absolutely counts as high molecular weight). Available from: https://www.ncbi.nlm.nih.gov/books/NBK557478/. The physician's compounds also contain potent anti-inflammatories like turmeric and niacinamide*. . But that doesnt matter, as long as result is achieved without compromising skin barrier or incurring inflammatory-irritation. Well, the answer is probably a no, but they do work to some extent. Retinol is a weaker retinoid as compared to tretinoin, which is an advantage to sensitive skin individuals. Because of its multitude of benefits, tretinoin is hailed as the gold standard for anti-aging and acne. Thanks to inflammation soothing properties, azelaic acid can be an excellent option for people looking to treat acne and rosacea. NADH, as a reduction agent, reduce the alcohol group to aldehydes. With years of professionalism and practice in the beauty industry, I've written hundreds of inspiring beauty tips expert-backed with facts and advices from board-certified Dermatologists, Estheticians and Cosmetologists. hydroquinone 4%, tretinoin 0.05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma. Otherwise, tretinoin may not work properly or skin irritation might occur. While niacinamide comes in many different forms: cleansers, toners, serums, etc., tretinoin just comes in a gel or cream form, which makes it a little bit easier! Azelaic Acid is effective during all stages of acne 1: it reduces active acne, it helps clear up the redness, scarring, and hyperpigmentation that acne can cause, and it keeps acne bacteria at bay once your skin has healed. Altreno (tretinoin lotion) package insert; Bridgewater, NJ: Valeant Pharmaceuticals North America LLC; 2018 Aug. Renova 0.02% (tretinoin cream) package insert; Bridgewater, NJ: Valeant Pharmaceuticals North America LLC; 2013 Jun. Azelaic Acid + Niacinamide, Vitamin C. y l b 3 kt hp hon ho gip h tr iu tr nm lnh tnh, an ton cho da. No tyrosinase enzyme = no melanin production. Example: I use them on Monday, I skip Tuesday and use them again on Wednesday, just like that. Combined with polyacrylate-13 and polysorbate 20, it forms a very effective tickener-emulsifier trio. Also if you have a sensitive skin and concerned about using these two actives together, Ill recommend you use them apart or in separate times. Retinoids can work to promote healthy skin cells, while azelaic acid can reduce inflammation and prevent irritation and breakouts caused by the retinoid. Azelaic acid is a skincare ingredient found in wheat and barley, with antibacterial and anti-inflammatory properties that help keep skin clear. Like this, the products can stay more stable over time. I'm so glad you're here! In fact, many custom prescriptions like Curology and Apostrophe actually combine tretinoin and niacinamide in the same formula. The BeautyBrains blog made a fantastic article about ceramides and they have listed a couple of examples about studies showing that ceramides - especially when used in certain ratios with cholesterol and fatty acids - do hydrate the skin and can help to repair the skin barrier. Here's an example of how to use tretinoin and niacinamide together. Tretinoin is a powerful exfoliator that can cause redness, irritation, flaking, dryness and peeling, especially when you first start using it. Also, has some antimicrobial activity so it can help to boost the effectiveness of the preservative system. Combined with polyacrylate-13 and polysorbate 20, it forms a very effective tickener-emulsifier trio. Base Ingredients: Caprylic/capric triglycerides . The active ingredients in this preparation are indicated for the topical treatment of inflammatory acne vulgaris. also, i use 15% azelaic acid, even though some people think it is irritating. However, both ingredients are suitable for all skin types . It was a sweep-off. Tretinoin is a prescription-only form of Vitamin A that speeds up skin cell turnover, making it excellent for anything from acne to wrinkles. Dont forget to start from lower concentration and build your way up (if need be). Then 3 times the following week, increasing the frequency this way until you are comfortable with daily use. Tretinoin helps to improve the appearance of acne, scarring, pigmentation and premature aging while niacinamide helps to soothe the skin, reduce redness and inflammation, fade hyperpigmentation and keep the skin hydrated. To treat acne marks, Lorscher recommends products with niacinamide, azelaic acid, and alpha hydroxy acids. Tretinoin is synthesized from beta-carotene.The beta-carotene is firstly cleaved into beta-carotene 15-15'-monooxygenase through site 1 double bond oxidized to epoxide.The epoxide is attacked by water to form diol in site 1. Your dermatology provider prescribes your formula . There is also research showing that panthenol can help our skin to produce more lovely lipids that are important for a strong and healthy skin barrier. Get that glow! S dng Azelaic Acid 20% tng t vic bn s dng Tretinoin 0,05%. And oh, dont let the word acid fool you, azelaic acid isnt a hard-hitter ingredient, or the kind that sensitizes the skin like retinoids, AHAs and BHA. Azelaic Acid c coi l "c cng" ca Niacinamide. Typically used at 1% or less in most formulations. Supported with key ingredients like niacinamide and azelaic acid. We wrote way more about ceramides at ceramide 1, so click here to know more. Niacinamide, azelaic acid, and Vitamin C are wonderful actives and have a host of skin benefits when approached correctly. We have written way more about ceramides at ceramide 1, so click here to know more. Retinol is a bit milder than its prescription counterparts and is often considered to be less effective, but thats not necessarily a bad thing! Once again azelaic acid compares almost identically. Research also shows that it might be useful for wound healing as it promotes fibroblast (nice type of cells in our skin that produce skin-firming collagen) proliferation. The ingredients. They also have a nice silicone feel with glide-on spreading. The Ordinary Natural Moisturizing Factors + HA, You can read my experimental-comparison review between The Ordinary & Paulas Choice azelaic acid 10%, I Used Niacinamide & Lactic Acid Together Heres My Review, I Used Niacinamide And Azelaic Acid From The Ordinary Brand & This Happened, Skin Purging Or Breaking Out? According to Joshua Zeichner, MD, director of cosmetic and clinical research at Mount Sinai Hospital, Unlike other acids, azelaic acid does not make you sensitive to the sun.. Plus, some ingredients, like benzoyl peroxide actually render the tretinoin ineffective. Apply any other skin care products that are compatible with tretinoin such as Green Tea Antioxidant Skin Therapy and Daily Moisturizing Face Cream. Very similarly to the Benzoyl Peroxide study, the Azelaic Acid cream was better tolerated and didn't cause the side . Were here to break down five popular skincare ingredients, including what they do and how you can add them to your routine. Here you'll find science-based skincare advice that gets results. Many of the acne-fighting effects of tretinoin also improve signs of aging, but its ability to promote collagen production helps create that "glow" in aging skinas well as improve other signs of aging. Tretinoin and Azelaic Acid. Heres an example of how to use tretinoin and niacinamide together, Step 1: Cleanse your face with a gentle cleanser and gently pat dry, Step 2: Apply niacinamide serum all over your face and wait a few minutes for it to absorb, Step 3: Apply tretinoin cream all over your face. When it comes to tretinoin, you can bend this rule a little and use a moisturizer before tretinoin, which can help buffer the active ingredients and reduce any potential irritation or other side effects. Elizabeth is here to help decode the science behind skincare and with a background in chemistry and microbiology, she's a pro at deconstructing scientific studies and medical jargon. Since tretinoin is only available with a prescription, youll need to either start a chat with your Curology provider or visit an in-person medical provider. Azelaic acid occurs naturally in some whole grains, but its generally safe to use topically for those with celiac disease or gluten sensitivities. Vic kt hp Azelaic Acid v Niacinamide l hon ton hp l. It also reduces free fatty acid production, part of the pathogenesis of acne . Azelaic acid is a naturally occurring acid found in grains such as barley, wheat, and rye. All acne breakouts wiped-off without a trace. After using these duo-actives every-other-day for three (3) weeks, at night time only, Ive come to share my honest experience with these acids, but before I plunge into that, lets know what these ingredients are and what they do for the skin. It contains niacinamide, or vitamin B3, which has been shown to reverse sun damage and even out pigment. Nhng c bit l Azelaic Acid li du nh v t tc dng ph. Naturium Azelaic Acid Emulsion 10% Plus Bioactive Brightening Complex & Niacinamide, Aging Skin Treatment, 1 oz. after cleansing and before or after moisturizing, depending on your skin's sensitivity . In fact, using these two ingredients together can give you even more powerful results. Azelaic acid is an antioxidant naturally produced on your skin, and its lab-engineered form is available as a gel, foam, or cream. . Retinoids + AHA/BHA. If youve heard the term retinoid and thought it sounded similar to retinol, youre right! For a new user trying to ease into Tretinoin, especially for those with sensitive skin, it's best to use it no more than twice the first week. It is published by the Personal Care Product Council. For every script written, Skin Medicinals donates a portion of proceeds to non-profits . TRENDING POST: Drmtlgy Needleless Serum Review. While niacinamide doesnt have too many side effects, tretinoin can come along with a few. Tretinoin is a form of vitamin A that helps the skin to renew itself more quickly. It's also a solvent, humectant and to some extent a penetration enhancer. A mild, natural preservative that usually comes to the formula together with its other mild preservative friends, such as Benzoic Acid and/orDehydroaceticAcid. Yes, niacinamide and retinol can be used together without any issues! Tretinoin / Azelaic Acid / Niacinamide Cream is a combination of prescription drug products that have been formulated into a hypoallergenic cream to address acne vulgaris as well as rosacea. After clearing the way, tretinoin welcomes in fresh, plump skin cells and gives them the support they need by stimulating the production of collagen: a protein that helps with skin firmness. This, in turn, helps reduce the appearance of fine lines and wrinkles. New skin cells lead to your skin looking brighter and more even. While mild cases of acne may respond well to over-the-counter treatments, stubborn cases require stronger treatments. Step 3: Apply tretinoin cream all over your face. Azelaic acid is a skin-friendly dicarboxylic acid with unique properties that works by inhibiting misbehaving elements on and within skin's uppermost layers (1). Helpful. Prior studies have shown that kojic acid and niacinamide used in combination or alone effectively reduce hyperpigmentation, including melasma. Benefits of Azelaic Acid for Skin. And ceramides are about 50% of those lipids (the other important ones are cholesterol with 25% and fatty acids with 15%). A handy helper ingredient that helps water and oil to mix nicely together. But you can safely mix them together if you prefer to use both tretinoin and niacinamide at the same time. BeautySparkReview provides content of general nature that is designed for informational purposes only. Tretinoin anti-aging benefits include: Promotes collagen production. A four-night skin cycling routine might include salicylic acid or glycolic acid on night one, followed by tretinoin on night two, followed by two recovery nights, during which no actives . Ingredients explained. Now the question is only this: If we put ceramides all over our face do theywork as well as ceramides already naturally in our skin? :) You are almost done: please check your mailbox to confirm your email! Heads up: Since tretinoin encourages new cell growth, it can cause sun sensitivityso its critical to apply sunscreen before going outside! With tretinoin helping to combat pigmentation to uneven skin tone and azelaic acid helping rid the skin of dead skin cells often which tends to make dark spots appear darker. But worry not! . Tretinoin cream available in 0.025%, 0.05%, 0.1% strengths with niacinamide 4%. You also want to be careful when using tretinoin with other exfoliating ingredients, such as glycolic acid. A pre-neutralised form of super common thickener, Carbomer. 6 Possible Reasons, Is Panoxyl Good For Acne? If youre wondering if tretinoin and azelaic acid can be used together, then the answer is yes, a research study which involves azelaic acid with the combination of topical medications such as benzoyl peroxide 4% gel, clindamycin 1% gel, tretinoin 0.025% cream, and erythromycin 3%, proved enhanced efficacy in treating acne. Another research study with the combination of 20% azelaic acid and tretinoin on patients with melasma showed that azelaic acid is superior to 4% hydroquinone, as tretinoin enhanced the skin lightening effect of azelaic acid onmelasma within three (3) months of treatment on patients. Chemically, this is definitely not true, as the two forms are almost the same, both are polymers and the subunits can be repeated in both forms as much as you like. Step 1: Cleanse your face with a gentle cleanser and gently pat dry. In the study of comedonal acne, 20% azelaic acid cream was equally effective as 0.05% tretinoin cream in reducing the number of comedones and with respect to overall response. Meet the gold standard for anti-aging. Can You Use Niacinamide With Hyaluronic Acid? Well, we shall know about that. And they are there in big amounts! Tretinoin (a metabolite of vitamin A) is the gold standard anti-aging ingredient that is also FDA-approved (and it's the only one so far!) How it works: Share your skin goals and snap selfies. Niacinamide can also help to brighten the skin and even out skin tone and keep the skins moisture barrier strong and healthy. Azelaic acid sounds technical, so you might be surprised to learn that it's a naturally occurring substance found in grains like wheat and barley. Side effects: It's one of the gentlest skin-lighteners available . Azelaic Acid Vs Benzoyl Peroxide: Is One Better Than The Other? Also, I dont use these acids every day, I use themevery-other-day. With a rsum like that, its no wonder that this ingredient has been growing a steady following in skincare! Interested in trying them out? Individuals with sensitive skin may experience side effects such as redness, swelling, and a slight burning sensation. But still endeavor to maintain the every-other-day application technique and not everyday. Please try again later! A film forming polymer that usually comesto the formula as part of athickener-emulsifier trio paired withPolyisobutene andPolysorbate 20. It usually comesto the formula as part of athickener-emulsifier trio paired withPolyisobutene andPolysorbate 20. Thanks. As always, apply the thinner product first, followed by the thicker product. It is also produced naturally by a certain fungus found on human skin. 2. Can You Use Salicylic Acid And Niacinamide Together? Retinoic acid irritates the skin and causes the cells of the skin to grow (divide) and die . I definitely think the azelaic acid is what saved me from a bad purge too, such a great . Pro-Vitamin B5 is a goodie that moisturises the skin, has anti-inflammatory, skin protecting and wound healing properties. As always, youll want to follow the thinnest to thickest rule. Azelaic acid. Its an effective ingredient to treat acne, hyperpigmentation, and premature aging. . Curious about how to layer 3 popular actives? As aforementioned, Im not new to acids, I know my way around acids. Related post: Can You Use Niacinamide With Azelaic Acid? Mixing tretinoin with other irritating ingredients can actually make the irritation and side effects worse. A: If youre an individual with super-senstive skin, and wish to go for retinol instead of tretinoin (which is the most potent of all retinoids), then youre definitely on the right track. Tretinoin is one of the strongest and most effective retinoids on the market. Ceramides make up 50% of the goopy stuff that's between our skin cells and play a super important role in having a healthy skin barrier and keeping the skin hydrated. It's a type of lipid, a so-calledsphingoid base that can be found naturally in the upper layer of the skin. Retinol Vs Retin-A: Whats The Difference? This is to enable me give a precise review about the combination of these two acids. A helper ingredient that's used as a co-emulsifier and as a stabilization agent for foams. Its main job in skincare products is to moisturise the skin. Azelaic acid exfoliates the skin more gently than glycolic, lactic, andsalicylic aciddoes. Disclaimer:This is a personal experience with the combination of Tretinoin and azelaic acid, you may have a whole different experience as skin type differs so as result differs too. Ceramides make up 50% of the goopy stuff that's between our skin cells and play a super important role in having a healthy skin barrier and keeping the skin hydrated. A handy white powder that magically converts a liquid into a nice gel formula. A type of lipid that can be found naturally in the skin. Our current one, Ceramide 1, or morerecently called CeramideEOP, was the first one that was identified in 1982 and it's a special snowflake. It is generally well tolerated when applied topically, however, mild to moderate itching and dry skin are possible side effects of azelaic acid.5, 6, 7, Niacinamide is the physiologically active form of niacin (vitamin B3). Avoid anything irritating while your skin is getting used to tretinoin- no scrubs, benzoyl peroxide, vitamin C, glycolic acid or salicylic acid. Does Hyaluronic Acid Help Acne? You can usually find it right in the very first spot of the ingredient list, meaning its the biggest thing out of all the stuff that makes up the product. A 2007 study showed thatPhytosphingosine even works againstevil acne-causing bacteria,Propionibacterium acnes and shows promise as a complementing active ingredient in treating acne-prone skin thanks to its anti-inflammatory and antimicrobial activities. Ok, so now we know what ceramides are, let's see what they do in our skin: research shows clearly that they play a super important role in keeping the skin barrier healthy and the skin hydrated. It's not only an anti-aging miracle but is also an effective acne treatment and skin lightener. In fact, the niacinamide can actually help to reduce the irritation from the tretinoin! As cosmetic chemist kindofstephenwrites on reddit "sodium hyaluronate disassociates into hyaluronic acid molecule and a sodium atom in solution". Xem thm: Review tr mn Tretinoin Gel USP 0.05 Obagi. It works even better when combined with its pal, Ceramide1. This can make your skin appear more youthful and radiant than it would if you used either product alone. A: While azelaic acid can be used both morning and night because it is a mild acid, tretinoin shouldnt. Don't forget to follow us on Instagram. But before we go into the details, let's just quickly define what the heck ceramides are: They are waxy lipids that can be found naturally in the outer layer of the skin (called stratum corneum - SC). . Since its not as strong, retinol can be found in some over-the-counter products, whereas you can only get tretinoin with a prescription from a medical provider. It belongs to a class of molecules known as retinoids, which is an umbrella term for all Vitamin A compounds and derivatives like retinol or adapalene. So, I decided its a good time to put tretinoin and azelaic acid together into the test, to see how really effective these duo-actives are in tackling superficial acne, because I have been longing to use these two active ingredients to test their efficacy. By blocking the production of unwanted pigmentation, it also helps . So ceramides form kind of a "water-proof" protecting layerand make sure that our skin remains nice and hydrated. Azelaic acid is an anti-keratinizing agent that prevents the buildup of dead skin cells, which can cause congestion. Pathophysiology of premature skin aging induced by ultraviolet light. A nice one to spot in the ingredient list. So, for the sake of your skin, limit tretinoin use at night-time only. Who said a perfect skin doesnt get imperfect? Its the most commonly used version of pure vitamin E in cosmetics. Its pH dependent and works best at acidic pH levels (3-5). Related post: Azelaic Acid or Benzoyl Peroxide For Acne. Layering azelaic acid and niacinamide can improve skin congestion, inflammatory congestion, and fade post-acne marks for even the most sensitive skin. As you might guess from the pro part, its a precursor to vitamin B5 (whose fancy name is pantothenic acid). In particular, Safflower Oleosomes are created from safflower seeds and carrysafflower seed oil and vitamin E. According to the manufacturer, oleosomes work both as natural emulsifiers as well as time-released delivery systems. The most common skincare ingredient of all. You can read my experimental-comparison review between The Ordinary & Paulas Choice azelaic acid 10%. This is to ease your way into these acids and to allow your skin gradually build tolerance or get accustomed to them. I skip the vitamin C in the morning but use the mix both morning and night. The azelaic acid is a topical antibiotic that evens out skin, kills the bacteria that cause . Also its very important to start from a low concentration, especially if you have a sensitive skin. In general, oleosomesare tiny-winy (micron sized) spheres that store emollient plant oils (+ some other things). Azelaic acid is well known to be a hater of acne, it kills acne causing bacteria(P. acnes) and cleanses the pores of pore-clogging impurities, all thanks to its mild exfoliating potentials. Micellar Water Vs Witch Hazel: Whats The Difference? Like, zayum gurl! . Even better--have a dermatologist . A typeof ceramidethat can be found naturally in the upper layer of the skin. This is another way to enjoy the benefits of these acid combos without irritation. Retinoids + vitamin C. may cause over-exfoliation . This is because, azelaic acid (being a mild acid and exfoliant) can tend to cause skin-irritation when applied on moist skin as a result of increased absorption. A: While using tretinoin and azelaic acid together, I had no irritation, this is because I played smart. Chemically speaking, ceramides are the connection of a fatty acid and a sphingoid base and both parts can have different variations that result in the different types of ceramides. I have done a month of 0.025 and just started 0.05, using daily. Apart from being an important skin-identical ingredient, it's also an emollient and stabilizer. What do we know, right? ), It's an all around skin issue fixer as it works at the skin cell level and makes your skin cells behave in a healthy and normal way, It makes the skin less wrinkled, firmer, smoother and tighter, everything you could want from an anti-aging ingredient, It's also an effective acne treatment. Other benefits of the compound may include the reduction of fine lines and wrinkles and the lessening of hyperpigmentation. A polymer (big molecule from repeated subunits) that's used as a gloss improver for lipsticks and lipglosses. Although previously, I have practically testedniacinamide and azelaic acid togetheron their efficacy in treating acne, and the result was mind-blowing. Do not flush unused medications or pour down a sink or drain. Salicylic Acid Vs Glycolic Acid: Whats The Difference? While other redditors followed suit. Your dermatology provider prescribes your formula. Fluocinolone, hydroquinone, and tretinoin topical may also be used for purposes not listed in this medication . It works on the skin cell level and makes your skin cells behave in a healthy and normal way. Some of these ingredients are ones that your Curology provider can potentially prescribe to you. Context and objective: Acne vulgaris, an inflammatory skin disease with different clinical appearances, is a common problem in most adolescents. If youre using tretinoin gel and moisturizer, apply the tretinoin gel, wait a few minutes then follow with the niacinamide moisturizer. Background: Acne is an inflammatory disorder with a high global burden. I'm also considering experimenting with The Ordinary Niacinamide 10% + Zinc PCA 1% and rotating in The Ordinary Azelaic Acid Suspension 10% (either alternate nights with the glycolic, or alternate mornings with the Tretinoin). every 3rd day. Curology (Active: 0.25% Zinc Pyrithione, 4% Niacinamide, 4% Azelaic Acid // Inactive: Water, glycerin, aloe vera leaf juice, PEG-100 myristate, sweet almond seed oil, xanthan gum, methyl paraben, propyl paraben, tocopheryl acetate.)

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